On September 17, of 1925, Kahlo was riding in a bus when the vehicle collided with a trolley car. She suffered serious injuries in the accident, including a broken spinal column , a broken collarbone, broken ribs, a broken pelvis, eleven fractures in her right leg, dislocated right foot and a dislocated shoulder. An iron handrail pierced her abdomen and her uterus, which seriously damaged her reproductive ability.
Although she recovered from her injuries and eventually regained her ability to walk, she suffered all her life. She had thirty-five operations as a result of the accident.